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Understanding Common Insomnia Treatments in Adults

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Trial Objectives


Chronic insomnia is a serious health concern that affects around 10% of people in America. Current treatments are varied, and often target things that may result in sleep disruption. In this study, researchers are evaluating two common treatments for insomnia in adults to learn more about how they treat symptoms.

In the first phase of the study, all participants will receive cognitive behavior therapy for insomnia (CBT-I) treatment. Some participants will then enter a second study phase where they will receive either trazodone or a placebo (a medication containing no active ingredient).

Volunteers in this study will undergo overnight sleep studies and will have to take blood pressure readings and saliva samples at home. They also will complete questionnaires about their symptoms during clinic and telehealth visits, as well as at home.

Who Can Participate


Adults who live in Colorado and have chronic insomnia (difficulty sleeping at least three times per week lasting at least three months).

Age: 18+ Gender: Any

Estimated Time Commitment


Visits and home data collection over approximately 9-12 months. Some visits can occur virtually.

Payment & Reimbursement


Payment: Provided

Travel Reimbursement: Not Available

Trial Contact


For more information, contact:


Roxane Horberg
303.270.2850


Rachel Johnson
303.398.1058

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Trial Location


National Jewish Main Campus, Denver, CO

Trial Sponsors


National Heart, Lung, and Blood Institute (NHLBI)

Principal Investigators

Elizabeth Devon Smith

Elizabeth Devon Smith, PhD

Co-Investigators

Jennifer L. Taylor-Cousar

Jennifer L. Taylor-Cousar, MD, MSCS

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